Trading mtDNA uncovers its role in metastasis.

doi:10.4161/cam.3.1.6838

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Article

Trading mtDNA uncovers its role in metastasis.

Cell adhesion & migration - 1 Jan 2000

Ishikawa Kaori, Hayashi Jun-Ichi

Abstract excerpt

It has been controversial for many years of whether mtDNA mutations are involved in phenotypes related to cancer due to the difficulty in excluding possible involvement of nuclear DNA mutations in these phenotypes. We addressed this issue by complete trading of mtDNAs between tumor cells expressing different metastatic phenotypes. Resultant trans-mitochondrial cybrids share the same nuclear background, but...

Topics

Animals
DNA, Mitochondrial
Humans
Mice
Models, Biological
Mutation
Neoplasm Metastasis
Phenotype
Reactive Oxygen Species

Source

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Identifiers

PMID: 19372745
DOI: 10.4161/cam.3.1.6838
PMCID: PMC2675141

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