Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of somatic mutations in the mitochondrial genome to the development of cancer and tolerance against anticancer drugs.

Oncogene - 7 Aug 2006

Ohta S

Abstract excerpt

Mitochondrial defects have long been suspected to play an important role in the development of cancer. Although most cancer cells harbor somatic mutations in mitochondrial DNA (mtDNA), the question of whether such mutations positively contribute to the development of cancer remained unclear. To c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Cell Nucleus
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Genome

Share to Mitochondria

Share to Mutation

Share to Neoplasms

Source

Identifiers

PMID: 16892089
DOI: 10.1038/sj.onc.1209602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16892089-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of somatic mutations in the mitochondrial genome to the development of cancer and tolerance against anticancer drugs.PMID 16892089Read ↗

Mitochondrial Dysfunction in Diseases, Longevity, and Treatment Resistance: Tuning Mitochondria Function as a Therapeutic Strategy.Semantic proximity Read ↗

Generation of mtDNA-exchanged cybrids for determination of the effects of mtDNA mutations on tumor phenotypes.Semantic proximity Read ↗

Trading mtDNA uncovers its role in metastasis.Semantic proximity Read ↗

Spotlight on the relevance of mtDNA in cancer.Semantic proximity Read ↗

Mitochondrial DNA mutations in cancer: a review.Semantic proximity Read ↗

Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs.Semantic proximity Read ↗

Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis.Semantic proximity Read ↗

The role of mitochondria transfer in cancer biological behavior, the immune system and therapeutic resistanceSemantic proximity Read ↗

The effect of mitochondrial transplantation therapy from different gender on inhibiting cell proliferation of malignant melanomaSemantic proximity Read ↗

Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma.Semantic proximity Read ↗

Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) gene.Semantic proximity Read ↗

Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.