Article
Nuclear DNA but not mtDNA controls tumor phenotypes in mouse cells.
Biochemical and biophysical research communications - 25 Feb 2005
Akimoto Miho, Niikura Mamoru, Ichikawa Masami, Yonekawa Hiromichi, Nakada Kazuto, Honma Yoshio, Hayashi Jun-Ichi
Abstract excerpt
Recent studies showed high frequencies of homoplasmic mtDNA mutations in various human tumor types, suggesting that the mutated mtDNA haplotypes somehow contribute to expression of tumor phenotypes. We directly addressed this issue by isolating mouse mtDNA-less (rho(0)) cells for complete mtDNA replacement between normal cells and their carcinogen-induced transformants, and examined the effect of the mtDNA...
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