Article
A Mutation in Mouse MT-ATP6 Gene Induces Respiration Defects and Opposed Effects on the Cell Tumorigenic Phenotype.
International journal of molecular sciences - 9 Jan 2023
Moreno-Loshuertos Raquel, Movilla Nieves, Marco-Brualla Joaquín, Soler-Agesta Ruth, Ferreira Patricia, Enríquez José Antonio, Fernández-Silva Patricio
Abstract excerpt
As the last step of the OXPHOS system, mitochondrial ATP synthase (or complex V) is responsible for ATP production by using the generated proton gradient, but also has an impact on other important functions linked to this system. Mutations either in complex V structural subunits, especially in mtDNA-encoded ATP6 gene, or in its assembly factors, are the molecular cause of a wide variety of human diseases, most of...
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