Article
Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jun 2012
Hashizume Osamu, Shimizu Akinori, Yokota Mutsumi, Sugiyama Atsuko, Nakada Kazuto, Miyoshi Hiroyuki, Itami Makiko, Ohira Miki, Nagase Hiroki, Takenaga Keizo, Hayashi Jun-Ichi
Abstract excerpt
It has been hypothesized that respiration defects caused by accumulation of pathogenic mitochondrial DNA (mtDNA) mutations and the resultant overproduction of reactive oxygen species (ROS) or lactates are responsible for aging and age-associated disorders, including diabetes and tumor development. However, there is no direct evidence to prove the involvement of mtDNA mutations in these processes, because it is...
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