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Article

DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity.

The Journal of clinical investigation - 1 Jul 2013

Callicott Joseph H, Feighery Emer L, Mattay Venkata S, White Michael G, Chen Qiang, Baranger David A A, Berman Karen F, Lu Bai, Song Hongjun, Ming Guo-li, Weinberger Daniel R

Abstract excerpt

Hippocampal development is coordinated by both extracellular factors like GABA neurotransmission and intracellular components like DISC1. We previously reported that SLC12A2-dependent GABA depolarization and DISC1 coregulate hippocampal neuronal development, and 2 SNPs in these genes linked to mRNA expression interactively increase schizophrenia risk. Using functional MRI, we now confirm this biological...

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Source

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Identifiers

PMID: 23921125
DOI: 10.1172/JCI67510
PMCID: PMC3999052

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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