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Article

Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory.

Archives of general psychiatry - 1 Nov 2005

Cannon Tyrone D, Hennah William, van Erp Theo G M, Thompson Paul M, Lonnqvist Jouko, Huttunen Matti, Gasperoni Timothy, Tuulio-Henriksson Annamari, Pirkola Tia, Toga Arthur W, Kaprio Jaakko, Mazziotta John, Peltonen Leena

Abstract excerpt

CONTEXT: Chromosome 1q42 is among several genomic regions showing replicated evidence of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this relationship remain to be identified. OBJECTIVE: To examine a series of haplotype blocks of single-nucleotide polymorphic markers from a segment of 1q42 spanning the disrupted-in-schizophrenia 1 (DISC1) and translin-associated factor X...

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Source

Identifiers

PMID: 16275808
DOI: 10.1001/archpsyc.62.11.1205

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory.PMID 16275808Read ↗

A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia.Semantic proximity Read ↗

DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic ImagingSemantic proximity Read ↗

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.Semantic proximity Read ↗

Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments.Semantic proximity Read ↗

Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.Semantic proximity Read ↗

Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.Semantic proximity Read ↗

Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population.Semantic proximity Read ↗

Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes.Semantic proximity Read ↗

Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.Semantic proximity Read ↗

The DISC locus in psychiatric illness.Semantic proximity Read ↗

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Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.Semantic proximity Read ↗

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