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Article

Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia.

Scientific reports - 5 May 2022

Guardiola-Ripoll Maria, Sotero-Moreno Alejandro, Almodóvar-Payá Carmen, Hostalet Noemí, Guerrero-Pedraza Amalia, Ramiro Núria, Ortiz-Gil Jordi, Arias Bárbara, Madre Mercè, Soler-Vidal Joan, Salvador Raymond, McKenna Peter J, Pomarol-Clotet Edith, Fatjó-Vilas Mar

Abstract excerpt

The DISC1 gene is one of the most relevant susceptibility genes for psychosis. However, the complex genetic landscape of this locus, which includes protective and risk variants in interaction, may have hindered consistent conclusions on how DISC1 contributes to schizophrenia (SZ) liability. Analysis from haplotype approaches and brain-based phenotypes can contribute to understanding DISC1 role in the neurobiology...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35513527
DOI: 10.1038/s41598-022-10660-8
PMCID: PMC9072540

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