Article
A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2008
Kvajo Mirna, McKellar Heather, Arguello P Alexander, Drew Liam J, Moore Holly, MacDermott Amy B, Karayiorgou Maria, Gogos Joseph A
Abstract excerpt
DISC1 is a strong candidate susceptibility gene for schizophrenia, bipolar disorder, and depression. Using a mouse strain carrying an endogenous Disc1 orthologue engineered to model the putative effects of the disease-associated chromosomal translocation we demonstrate that impaired Disc1 function results in region-specific morphological alterations, including alterations in the organization of newly born and...
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