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Article

DISC1 gene and affective psychopathology: a combined structural and functional MRI study.

Journal of psychiatric research - 1 Feb 2015

Opmeer Esther M, van Tol Marie-José, Kortekaas Rudie, van der Wee Nic J A, Woudstra Saskia, van Buchem Mark A, Penninx Brenda W, Veltman Dick J, Aleman André

Abstract excerpt

The gene Disrupted-In-Schizophrenia-1 (DISC1) has been indicated as a determinant of psychopathology, including affective disorders, and shown to influence prefrontal cortex (PFC) and hippocampus functioning, regions of major interest for affective disorders. We aimed to investigate whether DISC1 differentially modulates brain function during executive and memory processing, and morphology in regions relevant for...

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Source

Identifiers

PMID: 25533973
DOI: 10.1016/j.jpsychires.2014.11.014

Genes

DISC1

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Related research

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DISC1 gene and affective psychopathology: a combined structural and functional MRI study.PMID 25533973Read ↗

Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes.Semantic proximity Read ↗

DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia.Semantic proximity Read ↗

Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.Semantic proximity Read ↗

DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: a voxel-based morphometry (VBM) study.Semantic proximity Read ↗

Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.Semantic proximity Read ↗

Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding.Semantic proximity Read ↗

Effect of DISC1 SNPs on brain structure in healthy controls and patients with a history of psychosis.Semantic proximity Read ↗

Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.Semantic proximity Read ↗

No evidence of DISC1-associated morphological changes in the hippocampus, anterior cingulate cortex, or striatum in major depressive disorder cases and healthy controls.Semantic proximity Read ↗

The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia.Semantic proximity Read ↗

Additive sex-specific influence of common non-synonymous DISC1 variants on amygdala, basal ganglia, and white cortical surface area in healthy young adults.Semantic proximity Read ↗

Effects of a mis-sense DISC1 variant on brain activation in two cohorts at high risk of bipolar disorder or schizophrenia.Semantic proximity Read ↗

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