Article
Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jun 2005
Callicott Joseph H, Straub Richard E, Pezawas Lukas, Egan Michael F, Mattay Venkata S, Hariri Ahmad R, Verchinski Beth A, Meyer-Lindenberg Andreas, Balkissoon Rishi, Kolachana Bhaskar, Goldberg Terry E, Weinberger Daniel R
Abstract excerpt
Disrupted-in-schizophrenia 1 (DISC1) is a promising schizophrenia candidate gene expressed predominantly within the hippocampus. We typed 12 single-nucleotide polymorphisms (SNPs) that covered the DISC1 gene. A three-SNP haplotype [hCV219779 (C)-rs821597 (G)-rs821616 (A)] spanning 83 kb of the gene was associated with schizophrenia in a family-based sample (P = 0.002). A common nonconservative SNP (Ser704Cys)...
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