Article
Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding.
The European journal of neuroscience - 1 Nov 2008
Di Giorgio Annabella, Blasi Giuseppe, Sambataro Fabio, Rampino Antonio, Papazacharias Apostolos, Gambi Francesco, Romano Raffaella, Caforio Grazia, Rizzo Miriam, Latorre Valeria, Popolizio Teresa, Kolachana Bhaskar, Callicott Joseph H, Nardini Marcello, Weinberger Daniel R, Bertolino Alessandro
Abstract excerpt
A common nonsynonymous single nucleotide polymorphism leading to a serine-to-cysteine substitution at amino acid 704 (Ser(704)Cys) in the DISC1 protein sequence has been recently associated with schizophrenia and with specific hippocampal abnormalities. Here, we used multimodal neuroimaging to investigate in a large sample of healthy subjects the putative association of the Ser(704)Cys DISC1 polymorphism with in...
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