Article
Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.
Human genetics - 1 Apr 2010
Nicodemus Kristin K, Callicott Joseph H, Higier Rachel G, Luna Augustin, Nixon Devon C, Lipska Barbara K, Vakkalanka Radhakrishna, Giegling Ina, Rujescu Dan, St Clair David, Muglia Pierandrea, Shugart Yin Yao, Weinberger Daniel R
Abstract excerpt
The etiology of schizophrenia likely involves genetic interactions. DISC1, a promising candidate susceptibility gene, encodes a protein which interacts with many other proteins, including CIT, NDEL1, NDE1, FEZ1 and PAFAH1B1, some of which also have been associated with psychosis. We tested for epistasis between these genes in a schizophrenia case-control study using machine learning algorithms (MLAs: random...
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