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Article

Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism.

Molecular systems biology - 2 Jul 2013

Stout Gerdine J, Stigter Edwin C A, Essers Paul B, Mulder Klaas W, Kolkman Annemieke, Snijders Dorien S, van den Broek Niels J F, Betist Marco C, Korswagen Hendrik C, Macinnes Alyson W, Brenkman Arjan B

Abstract excerpt

Mutations in the daf-2 gene of the conserved Insulin/Insulin-like Growth Factor (IGF-1) pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is completely suppressed by deletion of Forkhead transcription factor daf-16. To uncover regulatory mechanisms coordinating this extension of life, we employed a quantitative proteomics strategy with daf-2 mutants in comparison with N2 and...

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Identifiers

PMID: 23820781
DOI: 10.1038/msb.2013.35
PMCID: PMC3734508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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