Article

Translational regulation of non-autonomous mitochondrial stress response promotes longevity

2019-01-29

Abstract excerpt

<h4>Summary</h4> Inhibition of mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans . To understand the roles of S6K-mediated translational regulation in this process, we performed genome-wide translational profiling and genetic screens to identify genes t...

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Literature Corpus work: 11bbf4fe-5c3d-597f-9bf8-4b5bcb09820f
DOI: 10.1101/533695

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