Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.

Genes & development - 15 Nov 2007

Samuelson Andrew V, Carr Christopher E, Ruvkun Gary

Abstract excerpt

Genetic and RNA interference (RNAi) screens for life span regulatory genes have revealed that the daf-2 insulin-like signaling pathway plays a major role in Caenorhabditis elegans longevity. This pathway converges on the DAF-16 transcription factor and may regulate life span by controlling the expression of a large number of genes, including free-radical detoxifying genes, stress resistance genes, and pathogen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Silencing
Share to Caenorhabditis elegans Proteins
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Helminth

Share to Genes, Reporter

Share to Insulin-Like Growth Factor I

Share to Receptor, Insulin

Share to Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 18006689
DOI: 10.1101/gad.1588907
PMCID: PMC2049198

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.PMID 18006689Read ↗

Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost.Semantic proximity Read ↗

Studies of Caenorhabditis elegans DAF‐2/insulin signaling reveal targets for pharmacological manipulation of lifespanSemantic proximity Read ↗

Regulation of C. elegans life-span by insulinlike signaling in the nervous system.Semantic proximity Read ↗

Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans.Semantic proximity Read ↗

Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan.Semantic proximity Read ↗

Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging StrategiesSemantic proximity Read ↗

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.Semantic proximity Read ↗

End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies.Semantic proximity Read ↗

DAF-16 target genes that control C. elegans life-span and metabolism.Semantic proximity Read ↗

Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegansSemantic proximity Read ↗

Genetics, life span, health span, and the aging process in Caenorhabditis elegans.Semantic proximity Read ↗

Lifespan regulation by evolutionarily conserved genes essential for viability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.