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Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegans

1 Nov 2022

Abstract excerpt

Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic genetic nematode model, which has been extensively utilized to identify molecular and cellular components that function...

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PMID: 36380728
DOI: 10.14348/molcells.2022.0097

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