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Article

Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression.

Genome research - 1 May 2005

Halaschek-Wiener Julius, Khattra Jaswinder S, McKay Sheldon, Pouzyrev Anatoli, Stott Jeff M, Yang George S, Holt Robert A, Jones Steven J M, Marra Marco A, Brooks-Wilson Angela R, Riddle Donald L

Abstract excerpt

We have identified longevity-associated genes in a long-lived Caenorhabditis elegans daf-2 (insulin/IGF receptor) mutant using serial analysis of gene expression (SAGE), a method that efficiently quantifies large numbers of mRNA transcripts by sequencing short tags. Reduction of daf-2 signaling in these mutant worms leads to a doubling in mean lifespan. We prepared C. elegans SAGE libraries from 1, 6, and...

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Identifiers

PMID: 15837805
DOI: 10.1101/gr.3274805
PMCID: PMC1088289

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