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Article

ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans

5 Jul 2019

Abstract excerpt

OBJECTIVE: Animal lifespan is controlled through genetic pathways that are conserved from nematodes to humans. Lifespan-promoting conditions in nematodes include fasting and a reduction of insulin/IGF signaling. Here we aimed to investigate the input of the Caenorhabditis elegans homologue of the mammalian rate-limiting lipolytic enzyme Adipose Triglyceride Lipase, ATGL-1, in longevity control. METHODS: We used a...

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Share to Adipose Tissue and Metabolism
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PMID: 31311719
DOI: 10.1016/j.molmet.2019.07.001

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