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Article

Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Dec 2016

Depuydt Geert, Shanmugam Nilesh, Rasulova Madina, Dhondt Ineke, Braeckman Bart P

Abstract excerpt

In Caenorhabditis elegans, cellular proteostasis is likely essential for longevity. Autophagy has been shown to be essential for lifespan extension of daf-2 insulin/IGF mutants. Therefore, it can be hypothesized that daf-2 mutants achieve this phenotype by increasing protein turnover. However, such a mechanism would exert a substantial energy cost. By using classical 35S pulse-chase labeling, we observed that...

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PMID: 26865495
DOI: 10.1093/gerona/glv221
PMCID: PMC5106850

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Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant.PMID 26865495Read ↗

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