Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism.

Journal of proteome research - 4 Apr 2014

Depuydt Geert, Xie Fang, Petyuk Vladislav A, Smolders Arne, Brewer Heather M, Camp David G, Smith Richard D, Braeckman Bart P

Abstract excerpt

The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression in response to reduced insulin/IGF-1 signaling, including the expression levels of metabolism-associated genes. Taking advantage of the recent developments in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Insulin-Like Growth Factor I

Share to Metabolic Networks and Pathways

Share to Proteome

Share to Proteomics

Share to Receptor, Insulin

Source

Open in PubMed Open full text

Identifiers

PMID: 24555535
DOI: 10.1021/pr401081b
PMCID: PMC3993954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism.PMID 24555535Read ↗

Metabotyping of Caenorhabditis elegans and their culture media revealed unique metabolic phenotypes associated to amino acid deficiency and insulin-like signaling.Semantic proximity Read ↗

Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Erratum to "Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans" [Mech. Ageing Dev. 127 (5) (2006) 458-472].Semantic proximity Read ↗

Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generationsSemantic proximity Read ↗

Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression.Semantic proximity Read ↗

Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism.Semantic proximity Read ↗

DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling.Semantic proximity Read ↗

Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity.Semantic proximity Read ↗

DAF-16 target genes that control C. elegans life-span and metabolism.Semantic proximity Read ↗

Glucose Induces Sensitivity to Oxygen Deprivation and Modulates Insulin/IGF-1 Signaling and Lipid Biosynthesis in<i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Glucose enrichment accelerates <i>C. elegans</i> reproductive aging via non-autonomous DAF-2/insulin-like receptor signaling in somatic tissuesSemantic proximity Read ↗

Alternate metabolism during the dauer stage of the nematode Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.