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Combinatorial transcriptomic and genetic dissection of insulin/IGF-1 signaling-regulated longevity in Caenorhabditis elegans.

Aging cell - 1 Jul 2024

Ham Seokjin, Kim Sieun S, Park Sangsoon, Kwon Hyunwoo C, Ha Seokjun G, Bae Yunkyu, Lee Gee-Yoon, Lee Seung-Jae V

Abstract excerpt

Classical genetic analysis is invaluable for understanding the genetic interactions underlying specific phenotypes, but requires laborious and subjective experiments to characterize polygenic and quantitative traits. Contrarily, transcriptomic analysis enables the simultaneous and objective identification of multiple genes whose expression changes are associated with specific phenotypes. Here, we conducted...

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Caenorhabditis elegans
Caenorhabditis elegans Proteins
Insulin
Insulin-Like Growth Factor I
Longevity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Insulin

Signal Transduction

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PMID: 38529797
DOI: 10.1111/acel.14151
PMCID: PMC11258480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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