Article
Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.
Molecular & cellular proteomics : MCP - 1 Dec 2013
Depuydt Geert, Xie Fang, Petyuk Vladislav A, Shanmugam Nilesh, Smolders Arne, Dhondt Ineke, Brewer Heather M, Camp David G, Smith Richard D, Braeckman Bart P
Abstract excerpt
Reduced signaling through the C. elegans insulin/insulin-like growth factor-1-like tyrosine kinase receptor daf-2 and dietary restriction via bacterial dilution are two well-characterized lifespan-extending interventions that operate in parallel or through (partially) independent mechanisms. Using accurate mass and time tag LC-MS/MS quantitative proteomics, we detected that the abundance of a large number of...
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