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Article

Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost.

Nature communications - 25 Oct 2022

Zhang Yan-Ping, Zhang Wen-Hong, Zhang Pan, Li Qi, Sun Yue, Wang Jia-Wen, Zhang Shaobing O, Cai Tao, Zhan Cheng, Dong Meng-Qiu

Abstract excerpt

Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2 doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 receptor gene is expressed and where it acts to regulate ageing. Using knock-in fluorescent reporters, we determined that daf-2 and its downstream transcription factor daf-16 are expressed ubiquitously. Using tissue-specific targeted...

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Identifiers

PMID: 36284093
DOI: 10.1038/s41467-022-33850-4
PMCID: PMC9596710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost.PMID 36284093Read ↗

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