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Article

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

Molecular cell - 23 May 2013

Fernández-Cid Alejandra, Riera Alberto, Tognetti Silvia, Herrera M Carmen, Samel Stefan, Evrin Cecile, Winkler Christian, Gardenal Emanuela, Uhle Stefan, Speck Christian

Abstract excerpt

In Saccharomyces cerevisiae and higher eukaryotes, the loading of the replicative helicase MCM2-7 onto DNA requires the combined activities of ORC, Cdc6, and Cdt1. These proteins load MCM2-7 in an unknown way into a double hexamer around DNA. Here we show that MCM2-7 recruitment by ORC/Cdc6 is blocked by an autoinhibitory domain in the C terminus of Mcm6. Interestingly, Cdt1 can overcome this inhibitory activity,...

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Source

Identifiers

PMID: 23603117
DOI: 10.1016/j.molcel.2013.03.026

Genes

MCM2
OCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.PMID 23603117Read ↗

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