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Article

The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.

The EMBO journal - 21 Dec 2005

Ying Carol Y, Gautier Jean

Abstract excerpt

Eukaryotes have six minichromosome maintenance (MCM) proteins that are essential for DNA replication. The contribution of ATPase activity of MCM complexes to their function in replication is poorly understood. We have established a cell-free system competent for replication in which all MCM proteins are supplied by purified recombinant Xenopus MCM complexes. Recombinant MCM2-7 complex was able to assemble onto...

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Source

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Identifiers

PMID: 16369567
DOI: 10.1038/sj.emboj.7600892
PMCID: PMC1356333

Genes

MCM2
MCM6
MCM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.PMID 16369567Read ↗

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