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Cryo-EM structure of DNA-unbound human MCM2–7 complex reveals new disease-relevant regulation

2025-06-03

Abstract excerpt

Chromatin loading of the hexameric replicative helicase MCM2–7 complex requires coordinated interactions with the origin recognition complex (ORC), CDC6, and CDT1. MCM2–7 not bound to DNA forms a single hexamer (SH) with an open DNA entry gate. Two MCM2–7 SHs are loaded sequentially to form the double hexamer (DH) that encircles the DNA duplex. Activated MCM2–7 then unwinds DNA and initiates DNA replication. Our c...

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Identifiers and source

Literature Corpus work
a5087540-b781-5771-9e35-d060dcc994d0
DOI
10.1101/2025.05.31.656953
Open publication

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Cryo-EM structure of DNA-unbound human MCM2–7 complex reveals new disease-relevant regulationDOI 10.1101/2025.05.31.656953
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