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Article

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.

The Journal of biological chemistry - 20 Apr 2007

Speck Christian, Stillman Bruce

Abstract excerpt

DNA replication, as with all macromolecular synthesis steps, is controlled in part at the level of initiation. Although the origin recognition complex (ORC) binds to origins of DNA replication, it does not solely determine their location. To initiate DNA replication ORC requires Cdc6 to target initiation to specific DNA sequences in chromosomes and with Cdt1 loads the ring-shaped mini-chromosome maintenance (MCM)...

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Identifiers

PMID: 17314092
DOI: 10.1074/jbc.M700399200
PMCID: PMC3033201

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Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.PMID 17314092Read ↗

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Evolution of DNA replication origin specification and gene silencing mechanisms.Semantic proximity Read ↗

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.Semantic proximity Read ↗

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.Semantic proximity Read ↗

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.Semantic proximity Read ↗

ATP bound to the origin recognition complex is important for preRC formation.Semantic proximity Read ↗

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The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.Semantic proximity Read ↗

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firingSemantic proximity Read ↗

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