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Article

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication.

Cell reports - 10 Mar 2020

Amin Aftab, Wu Rentian, Cheung Man Hei, Scott John F, Wang Ziyi, Zhou Zijing, Liu Changdong, Zhu Guang, Wong Chris Kong-Chu, Yu Zhiling, Liang Chun

Abstract excerpt

Eukaryotic DNA replication licensing is a prerequisite for, and plays a role in, regulating genome duplication that occurs exactly once per cell cycle. ORC (origin recognition complex) binds to and marks replication origins throughout the cell cycle and loads other replication-initiation proteins onto replication origins to form pre-replicative complexes (pre-RCs), completing replication licensing. However, how...

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Identifiers

PMID: 32160540
DOI: 10.1016/j.celrep.2020.02.046

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An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication.PMID 32160540Read ↗

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