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Article

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

Nature structural & molecular biology - 1 Nov 2005

Speck Christian, Chen Zhiqiang, Li Huilin, Stillman Bruce

Abstract excerpt

Binding of Cdc6 to the origin recognition complex (ORC) is a key step in the assembly of a pre-replication complex (pre-RC) at origins of DNA replication. ORC recognizes specific origin DNA sequences in an ATP-dependent manner. Here we demonstrate cooperative binding of Saccharomyces cerevisiae Cdc6 to ORC on DNA in an ATP-dependent manner, which induces a change in the pattern of origin binding that requires the...

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Identifiers

PMID: 16228006
DOI: 10.1038/nsmb1002
PMCID: PMC2952294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.PMID 16228006Read ↗

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Semantic proximity Read ↗

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.Semantic proximity Read ↗

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.Semantic proximity Read ↗

ATP bound to the origin recognition complex is important for preRC formation.Semantic proximity Read ↗

Two subunits of human ORC are dispensable for DNA replication and proliferationSemantic proximity Read ↗

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication.Semantic proximity Read ↗

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.Semantic proximity Read ↗

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.Semantic proximity Read ↗

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Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex.Semantic proximity Read ↗

Evolution of DNA replication origin specification and gene silencing mechanisms.Semantic proximity Read ↗

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