ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

doi:10.1038/nsmb1002

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Article

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

Nature structural & molecular biology - 1 Nov 2005

Speck Christian, Chen Zhiqiang, Li Huilin, Stillman Bruce

Abstract excerpt

Binding of Cdc6 to the origin recognition complex (ORC) is a key step in the assembly of a pre-replication complex (pre-RC) at origins of DNA replication. ORC recognizes specific origin DNA sequences in an ATP-dependent manner. Here we demonstrate cooperative binding of Saccharomyces cerevisiae Cdc6 to ORC on DNA in an ATP-dependent manner, which induces a change in the pattern of origin binding that requires the...

Topics

Amino Acid Sequence
Cell Cycle Proteins
DNA
DNA Footprinting
DNA Primers
Electrophoretic Mobility Shift Assay
Microscopy, Electron
Models, Molecular
Molecular Sequence Data
Multiprotein Complexes
Mutation
Origin Recognition Complex
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 16228006
DOI: 10.1038/nsmb1002
PMCID: PMC2952294

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