Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The MCM Complex: Its Role in DNA Replication and Implications for Cancer Therapy

1 Aug 2005

Abstract excerpt

The MCM complex controls the once per cell cycle DNA replication in eukaryotic cells. In a process known as DNA replication licensing, it primes chromatin for DNA replication by binding origins of DNA replication during the late M to early G1 phase of the cell cycle. Activated by S phase promoting protein kinases, the origin-bound MCM complexes unwind the double stranded DNA at the origins, recruit DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 16101384
DOI: 10.2174/1568009054629654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MCM Complex: Its Role in DNA Replication and Implications for Cancer TherapyPMID 16101384Read ↗

MCM2 in human cancer: functions, mechanisms, and clinical significanceSemantic proximity Read ↗

MCM family in gastrointestinal cancer and other malignancies: From functional characterization to clinical implicationSemantic proximity Read ↗

Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseasesSemantic proximity Read ↗

Replication proteins and human disease.Semantic proximity Read ↗

Pan-Cancer Multi-Omics Analysis of Minichromosome Maintenance Proteins (MCMs) Expression in Human CancersSemantic proximity Read ↗

The CMG helicase and cancer: a tumor "engine" and weakness with missing mutations.Semantic proximity Read ↗

MCM proteins as diagnostic and prognostic tumor markers in the clinical setting.Semantic proximity Read ↗

[Structure and function of the MCM family proteins].Semantic proximity Read ↗

Elevated Levels of Mcm7 Disrupt Microtubule and Nucleolar Homeostasis to Drive Genome Instability and Cell DeathSemantic proximity Read ↗

Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.Semantic proximity Read ↗

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.Semantic proximity Read ↗

MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.