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Article

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.

Nucleic acids research - 1 Feb 2014

Evrin Cecile, Fernández-Cid Alejandra, Riera Alberto, Zech Juergen, Clarke Pippa, Herrera M Carmen, Tognetti Silvia, Lurz Rudi, Speck Christian

Abstract excerpt

The replicative mini-chromosome-maintenance 2-7 (MCM2-7) helicase is loaded in Saccharomyces cerevisiae and other eukaryotes as a head-to-head double-hexamer around origin DNA. At first, ORC/Cdc6 recruits with the help of Cdt1 a single MCM2-7 hexamer to form an 'initial' ORC/Cdc6/Cdt1/MCM2-7 complex. Then, on ATP hydrolysis and Cdt1 release, the 'initial' complex is transformed into an ORC/Cdc6/MCM2-7 (OCM)...

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Source

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Identifiers

PMID: 24234446
DOI: 10.1093/nar/gkt1148
PMCID: PMC3936773

Genes

MCM2
OCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.PMID 24234446Read ↗

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