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Article

A Meier-Gorlin syndrome mutation impairs the loading of the MCM2-7 complex during DNA replication initiation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2026

Liu Yusong, Yang Mengquan, Lu Ping, Gao Haishan, He Maozhou, Wang Yitao, Qi Ao, Cao Ting, Zhang Qiuqin, Qi Shutao, Shi Yigong, Yu Hongtao

Abstract excerpt

Chromatin loading of the hexameric replicative helicase MCM2-7 complex requires coordinated interactions with the origin recognition complex (ORC), CDC6, and CDT1. MCM2-7 not bound to DNA forms a single hexamer (SH) with an open DNA entry gate between MCM2 and MCM5. Two MCM2-7 SHs can be loaded sequentially to form the double hexamer (DH) that encircles the DNA duplex. Activated MCM2-7 then unwinds DNA and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41719335
DOI: 10.1073/pnas.2526022123
PMCID: PMC12933075

Genes

MCM2
MCM3
CDC6
CDT1
MCM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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A Meier-Gorlin syndrome mutation impairs the loading of the MCM2-7 complex during DNA replication initiation.PMID 41719335Read ↗

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