Article
ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.
Molecular cell - 22 Dec 2004
Bowers Jayson L, Randell John C W, Chen Shuyan, Bell Stephen P
Abstract excerpt
The origin recognition complex (ORC) is a six-subunit, ATP-regulated, DNA binding protein that is required for the formation of the prereplicative complex (pre-RC), an essential replication intermediate formed at each origin of DNA replication. In this study, we investigate the mechanism of ORC function during pre-RC formation and how ATP influences this event. We demonstrate that ATP hydrolysis by ORC requires...
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