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Article

Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.

The Journal of biological chemistry - 5 Sept 2008

You Zhiying, Masai Hisao

Abstract excerpt

Mcm4/6/7 forms a complex possessing DNA helicase activity, suggesting that Mcm may be a central component for the replicative helicase. Although Cdt1 is known to be essential for loading of Mcm onto the chromatin, its precise role in pre-RC formation and replication initiation is unknown. Using purified proteins, we show that Cdt1 forms a complex with Mcm4/6/7, Mcm2/3/4/5/6/7, and Mcm2/4/6/7 in glycerol gradient...

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Identifiers

PMID: 18606811
DOI: 10.1074/jbc.M803212200
PMCID: PMC3259827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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