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Article

Trimethoprim-metformin interaction and its genetic modulation by OCT2 and MATE1 transporters.

British journal of clinical pharmacology - 1 Nov 2013

Grün Barbara, Kiessling Michael K, Burhenne Jürgen, Riedel Klaus-Dieter, Weiss Johanna, Rauch Geraldine, Haefeli Walter E, Czock David

Abstract excerpt

AIMS: Metformin pharmacokinetics depends on the presence and activity of membrane-bound drug transporters and may be affected by transport inhibitors. The aim of this study was to investigate the effects of trimethoprim on metformin pharmacokinetics and genetic modulation by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1) polymorphisms. METHODS: Twenty-four healthy volunteers...

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Identifiers

PMID: 23305245
DOI: 10.1111/bcp.12079
PMCID: PMC3853537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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