Article
Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.
Clinical pharmacology and therapeutics - 1 Jun 2017
Dujic T, Zhou K, Yee S W, van Leeuwen N, de Keyser C E, Javorský M, Goswami S, Zaharenko L, Hougaard Christensen M M, Out M, Tavendale R, Kubo M, Hedderson M M, van der Heijden A A, Klimčáková L, Pirags V, Kooy A, Brøsen K, Klovins J, Semiz S, Tkáč I, Stricker B H, Palmer Cna, 't Hart L M, Giacomini K M, Pearson E R
Abstract excerpt
Therapeutic response to metformin, a first-line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants in metformin transporter genes, with inconsistent results. To clarify the significance of these variants in glycemic response to metformin in T2D, we performed a large-scale meta-analysis...
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