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Disposition of metformin: Variability due to polymorphisms of organic cation transporters

3 Mar 2011

Abstract excerpt

Considerable interindividual variability in clinical efficacy is recognized in the treatment of type 2 diabetes mellitus with the biguanide metformin. Metformin is a substrate of organic cation transporters, which play important roles in gastrointestinal absorption, renal and biliary elimination, and distribution to target sites of substrate drugs. This raises the question of whether genetic variations in these...

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PMID: 21366511
DOI: 10.3109/07853890.2010.549144

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