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Article

Influences of organic cation transporter polymorphisms on the population pharmacokinetics of metformin in healthy subjects.

The AAPS journal - 1 Apr 2013

Yoon Hwa, Cho Hea-Young, Yoo Hee-Doo, Kim Se-Mi, Lee Yong-Bok

Abstract excerpt

This study investigated the effects of genetic polymorphisms in organic cation transporter (OCT) genes, such as OCT1-3, OCTN1, MATE1, and MATE2-K, on metformin pharmacokinetics. Of particular interest was the influence of genetic polymorphisms as covariates on the variability in the population pharmacokinetics (PPK) of metformin using nonlinear mixed effects modeling (NONMEM). In a retrospective data analysis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23417334
DOI: 10.1208/s12248-013-9460-z
PMCID: PMC3675749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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