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Effects of single-nucleotide polymorphism on the pharmacokinetics and pharmacodynamics of metformin.

Expert review of clinical pharmacology - 1 Sept 2022

Li Shaoqian, Xu Bo, Fan Shangzhi, Kang Bo, Deng Lijing, Chen Danjun, Yang Bo, Tang Fan, He Zunbo, Xue Yong, Zhou Jie-Can

Abstract excerpt

INTRODUCTION: Metformin has been recognized as the first-choice drug for type 2 diabetes mellitus (T2DM). The potency of metformin in the treatment of type 2 diabetes has always been in the spotlight and shown significant individual differences. Based on previous studies, the efficacy of metformin is related to the single-nucleotide polymorphisms of transporter genes carried by patients, amongst which a variety...

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Share to Organic Cation Transporter 2
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoglycemic Agents

Share to Membrane Transport Proteins

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 36065506
DOI: 10.1080/17512433.2022.2118714

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