Article
Pharmacogenetic variation and metformin response.
Current drug metabolism - 1 Dec 2013
Chen Suning, Zhou Jie, Xi Miaomiao, Jia Yanyan, Wong Yan, Zhao Jinyi, Ding Likun, Zhang Jian, Wen Aidong
Abstract excerpt
Diabetes is a major health problem worldwide, and metformin, a traditional oral anti-hyperglycemic drug, is now believed to be the most widely prescribed antidiabetic drug. Metformin acts primarily by inhibiting hepatic glucose production and improving insulin sensitivity. Metformin is absorbed predominately by the small intestine and excreted in an unaltered form in the urine. The pharmacokinetics of metformin...
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