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Effects of genetic variants of organic cation transporters on metformin response in newly diagnosed patients with type 2 diabetes.

Medicine - 29 Nov 2024

AlKreathy Huda M, Alzahrani Abdulhhakim A, Esmat Ahmed, Damanhouri Zoheir A

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is a chronic disease that affects millions of people worldwide. Metformin is the optimal initial therapy for patients with T2DM. Genetic factors play a vital role in metformin response, including variations in drug efficacy and potential side effects. To determine the effects of genetic variants of multidrug and toxin extrusion protein 2 (MATE2), ataxia telangiectasia mutated...

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Identifiers

PMID: 39612420
DOI: 10.1097/MD.0000000000040684
PMCID: PMC11608742

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