Article

Quantitative contributions of hepatic and renal organic cation transporters to the clinical pharmacokinetic cimetidine-metformin interaction

2024-11-21

Abstract excerpt

<h4>ABSTRACT</h4> The widely prescribed oral anti-diabetic drug metformin is eliminated unchanged in the urine primarily through active tubular secretion. This process is mediated by organic cation transporter 2 (OCT2), an uptake transporter expressed on the basolateral membrane of renal proximal tubule cells. Metformin uptake into the liver, the site of action, is mediated by OCT1, which is expressed on the sinu...

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Literature Corpus work: a3abdafe-d4b6-521f-9080-51fa8f512c69
DOI: 10.1101/2024.11.19.624371

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