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Article

Genetic variation in organic cation transporters and considerations in drug development.

Expert opinion on drug metabolism & toxicology - 1 Mar 2023

Varma Manthena V S

Abstract excerpt

INTRODUCTION: Membrane transporters are now widely recognized for their role in the absorption, distribution, clearance, and elimination of drugs. The organic cation transporters (OCTs, SLC22A) are expressed in the intestine, liver, and kidneys and are of importance in determining systemic pharmacokinetics (PK) and tissue-specific exposure of drugs and metabolites. AREAS COVERED: An overview of the role of OCTs...

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PMID: 37070463
DOI: 10.1080/17425255.2023.2202813

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