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Clinical pharmacokinetics of metformin.

Clinical pharmacokinetics - 1 Feb 2011

Graham Garry G, Punt Jeroen, Arora Manit, Day Richard O, Doogue Matthew P, Duong Janna K, Furlong Timothy J, Greenfield Jerry R, Greenup Louise C, Kirkpatrick Carl M, Ray John E, Timmins Peter, Williams Kenneth M

Abstract excerpt

Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide developed from galegine, a guanidine derivative found in Galega officinalis (French lilac). Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive diffusion through cell membranes should be very limited. The mean ± SD fractional oral bioavailability...

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Identifiers

PMID: 21241070
DOI: 10.2165/11534750-000000000-00000

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