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Article

Current understanding of the pharmacogenomics of metformin.

Clinical pharmacology and therapeutics - 1 Dec 2009

Zolk O

Abstract excerpt

The identification of transporters for organic cations involved in the distribution and elimination of the antidiabetic compound metformin marks a milestone in the study of metformin's pharmacokinetics. This was followed by the urgent question of whether genetic variations in these transporters can affect efficacy and risk of adverse events associated with metformin use. After a brief historical review of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19915604
DOI: 10.1038/clpt.2009.144

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