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Article

Influence of OCT2 gene variants on metformin efficacy in type 2 diabetes: insights into pharmacogenomics and drug interactions.

Journal of translational medicine - 7 Aug 2025

Hatmal Ma'mon M, Abuyaman Omar, Al-Hatamleh Mohammad A I, Tayyem Heba, Olaimat Amin N, Mussa Ali, Aolymat Iman, Abuawad Aymen, Odeh Mohanad, Qawaqzeh Rana

Abstract excerpt

Metformin, a widely prescribed treatment for type 2 diabetes mellitus (T2DM), demonstrates significant inter-individual variability in its therapeutic response. This variability is potentially driven by genetic differences in drug transporters. Among these transporters, the organic cation transporter 2 (OCT2) plays a critical role in the pharmacokinetics of metformin by mediating its uptake into renal epithelial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40775340
DOI: 10.1186/s12967-025-06720-y
PMCID: PMC12333187

Genes

SLC22A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Influence of OCT2 gene variants on metformin efficacy in type 2 diabetes: insights into pharmacogenomics and drug interactions.PMID 40775340Read ↗

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Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes: A systematic review.Semantic proximity Read ↗

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A Review of the Impact of Pharmacogenetics and Metabolomics on the Efficacy of Metformin in Type 2 DiabetesSemantic proximity Read ↗

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Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.Semantic proximity Read ↗

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Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metforminSemantic proximity Read ↗

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