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Article

The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein.

PLoS biology - 1 Jan 2012

Xiong Xin, Hao Yan, Sun Kan, Li Jiaxing, Li Xia, Mishra Bibhudatta, Soppina Pushpanjali, Wu Chunlai, Hume Richard I, Collins Catherine A

Abstract excerpt

Axonal degeneration is a hallmark of many neuropathies, neurodegenerative diseases, and injuries. Here, using a Drosophila injury model, we have identified a highly conserved E3 ubiquitin ligase, Highwire (Hiw), as an important regulator of axonal and synaptic degeneration. Mutations in hiw strongly inhibit Wallerian degeneration in multiple neuron types and developmental stages. This new phenotype is mediated by...

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Identifiers

PMID: 23226106
DOI: 10.1371/journal.pbio.1001440
PMCID: PMC3514318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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