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An atypical ubiquitin ligase at the heart of neural development and programmed axon degeneration

1 Jan 2022

Abstract excerpt

The degeneration of nerve fibres following injury was first described by Augustus Waller over 170 years ago. Initially assumed to be a passive process, it is now evident that axons respond to insult via regulated cellular signaling events resulting in their programmed degeneration. Pro-survival and pro-degenerative factors have been identified and their regulatory mechanisms are beginning to emerge. The ubiquitin...

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PMID: 35535869
DOI: 10.4103/1673-5374.338992

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