Article

A dNmnat-sensitized <i>in vivo</i> platform for unbiased discovery of regulators of neurodegeneration

2025-09-25

Abstract excerpt

Axon degeneration drives nervous system dysfunction in diverse neurological diseases and injuries. While key regulators of injury-induced Wallerian degeneration have been identified, approaches have largely relied on axotomy, a particularly extreme injury for a neuron. Here, we developed a forward genetic screening platform in the adult Drosophila wing that sensitizes neurons to degeneration through depletion of...

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Literature Corpus work: 6f1d591c-fbb5-5903-9e91-a51eceeeaf76
DOI: 10.1101/2025.09.25.678663

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